TY - JOUR AU - Maia, José Roberto da Silveira AU - Santos, Ane Francielly da Silva AU - Souza, Marcia Cristina de AU - Diniz, Renata PY - 2018/01/23 Y2 - 2024/03/28 TI - NOVEL ZINC(II) DERIVATIVES OF PHENOL SCHIFF BASES: SYNTHESIS, CHARACTERISATION, CRYSTAL STRUCTURE AND ANTIMICROBIAL ACTIVITY JF - The Journal of Engineering and Exact Sciences JA - J. Eng. Exact Sci. VL - 4 IS - 1 SE - Inorganic Chemistry DO - 10.18540/jcecvl4iss1pp0019-0027 UR - https://periodicos.ufv.br/jcec/article/view/2471 SP - 0019-0027 AB - <p><span style="font-size: x-small;"><span style="font-family: Times New Roman;"><strong> </strong><em>Zinc(II)-Schiff base derivatives of general formula [Zn(L)Cl]<sub>n</sub>.xH<sub>2</sub>O {n = 2; x = 1, L = 3-hmp (<strong>1</strong>), L = 4-hmp (<strong>2</strong>); x = 0, L = hmyp (<strong>3</strong>)} were synthesized by the condensation reaction of aminophenol with 2-hydroxybenzaldehyde. The Schiff bases in complex-<strong>1</strong>, <strong>2</strong> and <strong>3</strong> are bonded to the metal through the nitrogen and oxygen atoms. These complexes have dimeric structures with bridging oxygen atoms; the metal is at the centre of a tetrahedron in complex-<strong>1</strong> and <strong>2</strong>, and at the centre of a square pyramidal geometry in complex-<strong>3</strong> according to the X-ray diffraction analyses. They were characterized by IR, NMR (<sup>1</sup>H, <sup>13</sup>C), molar conductivity, melting point and microanalyses. The bioassay of these Zn(II) derivatives on strains of S. aureus, B. subtillis, E. coli and S. typhimurium showed minimum inhibitory concentration (MIC) between 60 and 520 µM which is within the range reported in the literature for Zn(II)-Schiff base compounds. Complex-<strong>2</strong> showed the best antibacterial result with MIC of 65 µM on the Gram-positive S. aureus and B. subtillis bacteria.</em></span></span></p><p><span style="font-size: x-small;"><span style="font-family: Times New Roman;"><em><em>Compostos de zinc(II) com bases de Schiff de fórmula geral [Zn(L)Cl]<sub>n</sub>.xH<sub>2</sub>O {n = 2; x = 1, L = 3-hmp (<strong>1</strong>), L = 4-hmp (<strong>2</strong>); x = 0, L = hmyp (<strong>3</strong>)} foram preparados mediante reação de condensação entre aminofenol com 2-hidroxibenzaldeído. As bases de Schiff nos complexos <strong>1</strong>, <strong>2</strong> e <strong>3</strong> formam ligações ao centro metálico via os átomos de nitrogênio e oxigênio. Estes compostos têm uma estrutura dimérica com átomos de oxigênio em ponte. O metal se encontra no centro de um tetraedro (<strong>1</strong> e <strong>2</strong>) e de uma pirâmide de base quadrada (<strong>3</strong>), segundo análise por difração de raios-X. Os compostos foram caracterizados por IR, RMN (<sup>1</sup>H e <sup>13</sup>C), condutividade molar, pontos de fusão e microanálise. Ensaios biológicos em cepas de S. aureus, B. subtillis, E. coli e S. typhimurium mostraram MICs entre 60 e 520 µM. O complexo <strong>2</strong> mostrou o melhor resultado bactericida com MIC de 65 µM contra as bactérias Gram-positivas.</em><br /></em></span></span></p> ER -