EXERCÍCIO FÍSICO ALTERA A MORFOLOGIA DE CARDIOMIÓCITOS EM CAMUNDONGOS KNOCKOUT PARA OS RECEPTORES ?2-ADRENÉRGICOS

Authors

  • Aurora Corrêa Rodrigues Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil
  • Antônio José Natali Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil
  • Daise Nunes Queiroz da Cunha Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil
  • Alexandre Jayme Lopes Dantas Costa Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil
  • Anselmo Gomes de Moura Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil
  • Miguel Araujo Carneiro-Júnior Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil
  • Leonardo Bonato Felix Departamento de Engenharia Elétrica, Universidade Federal de Viçosa, MG, Brasil
  • Patrícia Chakur Brum Escola de Educação Física e Esporte, Universidade de São Paulo, SP, Brasil. Estudo financiado pela FAPEMIG (APQ-01449-13; BPD-00118-14).
  • Thales Nicolau Prímola- Gomes Laboratório de Biologia do Exercício, Departamento de Educação Física, Universidade Federal de Viçosa, Viçosa, MG, Brasil

Keywords:

physical activity, heart, hypertrophy

Abstract

The aim of this study was to investigate the effects of endurance training on the morphological properties of isolated left ventricle (LV) myocytes from ?2-adrenergic receptors knockout mice (KO ?2). Fourmonth old FVB/N and KO ?2 mice were randomly allocated into one of the 4 groups: FVBc, FVBt, KO ?2c e KO ?2t. The animals from FVBt, KO ?2t groups were submitted to a protocol of aerobic training 8 weeks, 5 days/week, 1 hour/day, intensity of 60% of maximal speed. At sacrifice, the heart was removed and LV myocytes were enzymatically dispersed. Cell length and width were measured using an image capture system and cell volume was calculated. The results showed that KO ?2t group showed higher cell length compared to the KO ?2c group. In conclusion, the aerobic training protocol increases the length of LV myocytes in KO ?2 mice. This change is compatible with eccentric cardiac hypertrophy.

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Published

2016-10-30

How to Cite

Rodrigues, A. C. ., Natali, A. J. ., Cunha, D. N. Q. da ., Costa, A. J. L. D. ., Moura, A. G. de ., Carneiro-Júnior, M. A. ., Felix, L. B. ., Brum, P. C. ., & Gomes, T. N. P.-. (2016). EXERCÍCIO FÍSICO ALTERA A MORFOLOGIA DE CARDIOMIÓCITOS EM CAMUNDONGOS KNOCKOUT PARA OS RECEPTORES ?2-ADRENÉRGICOS. Revista Mineira De Educação Física, 24(3), 81–93. Retrieved from https://periodicos.ufv.br/revminef/article/view/9912

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