ANTIMICROBIAL EFFECT OF ORGANOTIN COMPOUNDS DERIVED FROM PHENOLIC SCHIFF BASES

Ane Francielly da Silva Santos; José Roberto da Silveira Maia

doi:10.18540/jcecvl5iss5pp0452-0459

Authors

Ane Francielly da Silva Santos Federal Institute of Mato Grosso
José Roberto da Silveira Maia Universidade federal de Viçosa https://orcid.org/0000-0001-5715-8763

DOI:

https://doi.org/10.18540/jcecvl5iss5pp0452-0459

Keywords:

Organotin(IV) compounds, Characterization, Antimicrobial effect, Bactericide

Abstract

Several organotin(IV) derivatives of phenolic Schiff bases were prepared and investigated by spectroscopic methods. These compounds were bioassayed to evaluate their bacterial effect against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Salmonella typhimurium) microorganisms. Dimeric and monomeric compounds were characterized by infrared in solid state. Metallic centers having penta-, hexa-, and heptacoordination were identified by multinuclear NMR (¹H, ¹³C and ¹¹⁹Sn) in solution. The di- and triorganotin(IV) derivatives were also investigated by conductimetric measurements in methanol, elemental analysis and melting point. The bioassay of these tin(IV) compounds showed that the best resulting activity was against S. aureus for the triphenyltin(IV) phenolic Schiff base derivatives, presenting MICs of 1.1 µM (0.6 mg mL^-1) and 2.2 µM (1.3 mg mL^-1).

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Author Biographies

Ane Francielly da Silva Santos, Federal Institute of Mato Grosso

Química / Química Inorgânica

José Roberto da Silveira Maia, Universidade federal de Viçosa

Departamento de Química / Química Inogânica

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