NOVEL ZINC(II) DERIVATIVES OF PHENOL SCHIFF BASES: SYNTHESIS, CHARACTERISATION, CRYSTAL STRUCTURE AND ANTIMICROBIAL ACTIVITY

Autores

  • José Roberto da Silveira Maia Universidade Federal de Viçosa, UFV
  • Ane Francielly da Silva Santos
  • Marcia Cristina de Souza
  • Renata Diniz

DOI:

https://doi.org/10.18540/jcecvl4iss1pp0019-0027

Palavras-chave:

Schiff bases, zinc(II) complexes, crystal structure, antibacterial activity

Resumo

Zinc(II)-Schiff base derivatives of general formula [Zn(L)Cl]n.xH2O {n = 2; x = 1, L = 3-hmp (1), L = 4-hmp (2); x = 0, L = hmyp (3)} were synthesized by the condensation reaction of aminophenol with 2-hydroxybenzaldehyde. The Schiff bases in complex-1, 2 and 3 are bonded to the metal through the nitrogen and oxygen atoms. These complexes have dimeric structures with bridging oxygen atoms; the metal is at the centre of a tetrahedron in complex-1 and 2, and at the centre of a square pyramidal geometry in complex-3 according to the X-ray diffraction analyses. They were characterized by IR, NMR (1H, 13C), molar conductivity, melting point and microanalyses. The bioassay of these Zn(II) derivatives on strains of S. aureus, B. subtillis, E. coli and S. typhimurium showed minimum inhibitory concentration (MIC) between 60 and 520 µM which is within the range reported in the literature for Zn(II)-Schiff base compounds. Complex-2 showed the best antibacterial result with MIC of 65 µM on the Gram-positive S. aureus and B. subtillis bacteria.

Compostos de zinc(II) com bases de Schiff de fórmula geral [Zn(L)Cl]n.xH2O {n = 2; x = 1, L = 3-hmp (1), L = 4-hmp (2); x = 0, L = hmyp (3)} foram preparados mediante reação de condensação entre aminofenol com 2-hidroxibenzaldeído. As bases de Schiff nos complexos 1, 2 e 3 formam ligações ao centro metálico via os átomos de nitrogênio e oxigênio. Estes compostos têm uma estrutura dimérica com átomos de oxigênio em ponte. O metal se encontra no centro de um tetraedro (1 e 2) e de uma pirâmide de base quadrada (3), segundo análise por difração de raios-X. Os compostos foram caracterizados por IR, RMN (1H e 13C), condutividade molar, pontos de fusão e microanálise. Ensaios biológicos em cepas de S. aureus, B. subtillis, E. coli e S. typhimurium mostraram MICs entre 60 e 520 µM. O complexo 2 mostrou o melhor resultado bactericida com MIC de 65 µM contra as bactérias Gram-positivas.

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Biografia do Autor

José Roberto da Silveira Maia, Universidade Federal de Viçosa, UFV

Departamento de Quimica / Quimica Inorganica

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Publicado

2018-01-23

Como Citar

Maia, J. R. da S., Santos, A. F. da S., Souza, M. C. de, & Diniz, R. (2018). NOVEL ZINC(II) DERIVATIVES OF PHENOL SCHIFF BASES: SYNTHESIS, CHARACTERISATION, CRYSTAL STRUCTURE AND ANTIMICROBIAL ACTIVITY. The Journal of Engineering and Exact Sciences, 4(1), 0019–0027. https://doi.org/10.18540/jcecvl4iss1pp0019-0027

Edição

Seção

Inorganic Chemistry

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