ANTIMICROBIAL EFFECT OF OLIGOMERIC COPPER(II) DERIVATIVES OF BIS(PYRIMIDIN-2-YLTHIO)- AND BIS(4,6-DIMETHYLPYRIMIDIN-2-YLTHIO)ALKANES

Auteurs

  • Ricardo Soares Mota Silva Universidade Federal de Viçosa
  • Márcia Cristina de Souza Universidade Federal de Juiz de Fora
  • Lilian Berlini Universidade Federal de Viçosa
  • José Roberto da Silveira Maia Universidade Federal de Viçosa
  • Renata Diniz Universidade Federal de Juiz de Fora
  • Nivaldo Lúcio Speziali Universidade Federal de Minas Gerais
  • Onkar Dev Dhingra Universidade Federal de Viçosa
  • Vanny Perpetua Ferraz Universidade Federal de Minas Gerais

DOI :

https://doi.org/10.18540/jcecvl2iss2pp001-017

Mots-clés :

Antimicrobial activity, Bis(pyrimidin-2-ylthio)alkanes, Oligomeric copper(II) complexes, Bactericide, Fungicide

Résumé

A novel series of copper(II) derivatives of bis(pyrimidin-2-ylthio)- and bis(4,6-dimethylpyrimidin-2-ylthio)alkane of general formula [CuxCly(L)z]n {x = 1, y = 2, z = 1, L = ptm (1), pte (2), dptm (4), dpte (5), dpth (6); x = 2, y = 4, z = 3, L = pth (3) were tested for antimicrobial activity. These complexes were characterized by elemental analysis, infrared spectroscopy (IR) and gel permeation chromatography (GPC). Complex-4, 5 and 6 have the metal at the center of a square planar geometry and in complex-1, 2 and 3 the metal is at the center a square pyramidal geometry. The structure of complex-4, determined by X-ray diffraction analysis, shows this compound as an oligomer with one-dimensional chain in zigzag conformation. The high average molecular mass (Mw) of these copper(II) complexes confirms their oligomeric character. Although the free ligands were inactive agaisnt the microorganisms tested, the copper(II) derivatives showed good antifungal and antibacterial inhibition against C. albicans, C. tropicalis, S. aureus and E. coli, more effective than Nystatin and Norfloxacin.

 

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Publiée

2016-03-01

Comment citer

Silva, R. S. M., Souza, M. C. de, Berlini, L., Maia, J. R. da S., Diniz, R., Speziali, N. L., Dhingra, O. D., & Ferraz, V. P. (2016). ANTIMICROBIAL EFFECT OF OLIGOMERIC COPPER(II) DERIVATIVES OF BIS(PYRIMIDIN-2-YLTHIO)- AND BIS(4,6-DIMETHYLPYRIMIDIN-2-YLTHIO)ALKANES. The Journal of Engineering and Exact Sciences, 2(2), 001–017. https://doi.org/10.18540/jcecvl2iss2pp001-017

Numéro

Rubrique

Inorganic Chemistry

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